Intersex related gene expression profiles in clams Scrobicularia plana: Molecular markers and environmental application.
Identifieur interne : 000175 ( Main/Exploration ); précédent : 000174; suivant : 000176Intersex related gene expression profiles in clams Scrobicularia plana: Molecular markers and environmental application.
Auteurs : Corina M. Ciocan [Royaume-Uni] ; Elena Cubero-Leon [Royaume-Uni] ; William J. Langston [Royaume-Uni] ; Nick Pope [Royaume-Uni] ; Keith Cornelius [Royaume-Uni] ; E M Hill [Royaume-Uni] ; Diana Alvarez-Munoz [Royaume-Uni] ; Paolo Indiveri [Royaume-Uni] ; Adelaide Lerebours [Royaume-Uni] ; Christophe Minier [France] ; Jeanette M. Rotchell [Royaume-Uni]Source :
- Marine pollution bulletin [ 1879-3363 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Biomarkers (metabolism), Bivalvia (genetics), Bivalvia (metabolism), Disorders of Sex Development, Environment, Environmental Monitoring (methods), Female, Gene Expression (drug effects), Gene Expression (physiology), Humans, Male, Testis (metabolism), Transcriptome, Water Pollutants, Chemical (analysis), Water Pollutants, Chemical (metabolism), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , analysis : Water Pollutants, Chemical.
- chemical , metabolism : Biomarkers, Water Pollutants, Chemical.
- drug effects : Gene Expression.
- genetics : Bivalvia.
- metabolism : Bivalvia, Testis.
- methods : Environmental Monitoring.
- physiology : Gene Expression.
- chemical , toxicity : Water Pollutants, Chemical.
- Animals, Disorders of Sex Development, Environment, Female, Humans, Male, Transcriptome.
Abstract
Intersex, the appearance of female characteristics in male gonads, has been identified in several aquatic species. It is a widespread phenomenon in populations of the bivalve, Scrobicularia plana, from the southwest coast of the U.K. Genes previously identified as differentially expressed (ferritin, testicular haploid expressed gene, THEG, proliferating cell nuclear antigen, PCNA; receptor activated protein kinase C, RACK; cytochrome B, CYB; and cytochrome c oxidase 1, COX1) in intersex clams relative to normal male clams, were selected for characterisation and an environmental survey of the Channel region. Transcripts were significantly differentially expressed at sites with varying intersex incidence and contaminant burdens. Significant correlations between specific gene expressions, key contaminants and sampling locations have been identified, though no single gene was associated with intersex incidence. The results highlight the difficulty in understanding the intersex phenomenon in molluscs where there is still a lack of knowledge on the control of normal reproduction.
DOI: 10.1016/j.marpolbul.2015.02.019
PubMed: 25746199
Affiliations:
- France, Royaume-Uni
- Angleterre, Haute-Normandie, Région Normandie, Sussex de l'Est
- Brighton, Falmer, Le Havre
- Université du Havre, Université du Sussex
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Le document en format XML
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Ciocan</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewes Road, Brighton BN2 4GJ, United Kingdom; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewes Road, Brighton BN2 4GJ, United Kingdom; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ</wicri:regionArea><wicri:noRegion>Brighton BN1 9QJ</wicri:noRegion></affiliation></author><author><name sortKey="Cubero Leon, Elena" sort="Cubero Leon, Elena" uniqKey="Cubero Leon E" first="Elena" last="Cubero-Leon">Elena Cubero-Leon</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire d'Ecotoxicologie, Universite du Havre, 25 Rue Philippe Lebon, BP540, 766058 Le Havre, France; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Laboratoire d'Ecotoxicologie, Universite du Havre, 25 Rue Philippe Lebon, BP540, 766058 Le Havre, France; School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ</wicri:regionArea><orgName type="university">Université du Havre</orgName><placeName><settlement type="city">Le Havre</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName></affiliation></author><author><name sortKey="Langston, William J" sort="Langston, William J" uniqKey="Langston W" first="William J" last="Langston">William J. 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Lerebours</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Institute of Marine Sciences, University of Portsmouth, Ferry Road, Eastney, Portsmouth PO4 9LY, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological Sciences, Institute of Marine Sciences, University of Portsmouth, Ferry Road, Eastney, Portsmouth PO4 9LY</wicri:regionArea><wicri:noRegion>Portsmouth PO4 9LY</wicri:noRegion></affiliation></author><author><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire d'Ecotoxicologie, Universite du Havre, 25 Rue Philippe Lebon, BP540, 766058 Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Ecotoxicologie, Universite du Havre, 25 Rue Philippe Lebon, BP540, 766058 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Rotchell, Jeanette M" sort="Rotchell, Jeanette M" uniqKey="Rotchell J" first="Jeanette M" last="Rotchell">Jeanette M. Rotchell</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological, Biomedical & Environmental Sciences, University of Hull, Cottingham Road, Hull HU6 7RX, United Kingdom. Electronic address: J.Rotchell@Hull.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological, Biomedical & Environmental Sciences, University of Hull, Cottingham Road, Hull HU6 7RX</wicri:regionArea><wicri:noRegion>Hull HU6 7RX</wicri:noRegion></affiliation></author></analytic><series><title level="j">Marine pollution bulletin</title><idno type="eISSN">1879-3363</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biomarkers (metabolism)</term><term>Bivalvia (genetics)</term><term>Bivalvia (metabolism)</term><term>Disorders of Sex Development</term><term>Environment</term><term>Environmental Monitoring (methods)</term><term>Female</term><term>Gene Expression (drug effects)</term><term>Gene Expression (physiology)</term><term>Humans</term><term>Male</term><term>Testis (metabolism)</term><term>Transcriptome</term><term>Water Pollutants, Chemical (analysis)</term><term>Water Pollutants, Chemical (metabolism)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Bivalvia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bivalvia</term><term>Testis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Environmental Monitoring</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disorders of Sex Development</term><term>Environment</term><term>Female</term><term>Humans</term><term>Male</term><term>Transcriptome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intersex, the appearance of female characteristics in male gonads, has been identified in several aquatic species. It is a widespread phenomenon in populations of the bivalve, Scrobicularia plana, from the southwest coast of the U.K. Genes previously identified as differentially expressed (ferritin, testicular haploid expressed gene, THEG, proliferating cell nuclear antigen, PCNA; receptor activated protein kinase C, RACK; cytochrome B, CYB; and cytochrome c oxidase 1, COX1) in intersex clams relative to normal male clams, were selected for characterisation and an environmental survey of the Channel region. Transcripts were significantly differentially expressed at sites with varying intersex incidence and contaminant burdens. Significant correlations between specific gene expressions, key contaminants and sampling locations have been identified, though no single gene was associated with intersex incidence. The results highlight the difficulty in understanding the intersex phenomenon in molluscs where there is still a lack of knowledge on the control of normal reproduction.</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Haute-Normandie</li><li>Région Normandie</li><li>Sussex de l'Est</li></region><settlement><li>Brighton</li><li>Falmer</li><li>Le Havre</li></settlement><orgName><li>Université du Havre</li><li>Université du Sussex</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Ciocan, Corina M" sort="Ciocan, Corina M" uniqKey="Ciocan C" first="Corina M" last="Ciocan">Corina M. Ciocan</name></noRegion><name sortKey="Alvarez Munoz, Diana" sort="Alvarez Munoz, Diana" uniqKey="Alvarez Munoz D" first="Diana" last="Alvarez-Munoz">Diana Alvarez-Munoz</name><name sortKey="Cornelius, Keith" sort="Cornelius, Keith" uniqKey="Cornelius K" first="Keith" last="Cornelius">Keith Cornelius</name><name sortKey="Cubero Leon, Elena" sort="Cubero Leon, Elena" uniqKey="Cubero Leon E" first="Elena" last="Cubero-Leon">Elena Cubero-Leon</name><name sortKey="Hill, E M" sort="Hill, E M" uniqKey="Hill E" first="E M" last="Hill">E M Hill</name><name sortKey="Indiveri, Paolo" sort="Indiveri, Paolo" uniqKey="Indiveri P" first="Paolo" last="Indiveri">Paolo Indiveri</name><name sortKey="Langston, William J" sort="Langston, William J" uniqKey="Langston W" first="William J" last="Langston">William J. Langston</name><name sortKey="Lerebours, Adelaide" sort="Lerebours, Adelaide" uniqKey="Lerebours A" first="Adelaide" last="Lerebours">Adelaide Lerebours</name><name sortKey="Pope, Nick" sort="Pope, Nick" uniqKey="Pope N" first="Nick" last="Pope">Nick Pope</name><name sortKey="Rotchell, Jeanette M" sort="Rotchell, Jeanette M" uniqKey="Rotchell J" first="Jeanette M" last="Rotchell">Jeanette M. Rotchell</name></country><country name="France"><region name="Région Normandie"><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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